65 year old man presented with progressive obstructive jaundice, and loss of weight over 6 months. He also complained of epigastric discomfort and occasional black stools.
The specimen consists of the duodenum which is longitudinally opened, with the attached pancreatic head. The Ampulla of Vater shows a polypoid tumour growing into the duodenal lumen. This causes narrowing of the Ampulla and hence obstructive jaundice. Ulceration can also give rise to upper gastrointestinal tract bleeding.